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Kanamycin sulfate
🥰Excellent
Catalog No. T0793Cas No. 25389-94-0
Alias Ophtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfate
Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.
Kanamycin sulfate
🥰Excellent
Purity: 99.96%
Catalog No. T0793Alias Ophtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfateCas No. 25389-94-0
Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $41 | In Stock | |
| 1 mL x 10 mM (in H2O) | $50 | In Stock |
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Purity:99.96%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas. |
| In vitro | METHODS: Human cell lines HEK293, OVCAR8 and CA46 were treated with Kanamycin sulfate (0-1 mM) and cell viability was measured using the CCK-8 assay. RESULTS: Kanamycin showed no cytotoxic effects in any of the cell lines. [1] METHODS: Mycobacteria H37Rv, H2, H37RvR-PAS, Ravenel, Kirchbergand and BCG were treated with Kanamycin sulfate (0.1-100 µg/mL) for 2 weeks and tested for antibacterial activity. RESULTS: Kanamycin showed good antimicrobial activity against various Mycobacterium species with MICs of 1 µg/mL and 5 µg/mL for Kirchbergand strains, respectively. [2] |
| In vivo | METHODS: To detect ototoxicity, Kanamycin sulfate (800 mg/kg) was administered subcutaneously to C57BL/6J mice twice daily for fifteen days. RESULTS: Different ototoxic regimens were evaluated by ABR and DPOAE measurements before and after treatment. Sensory cell loss was quantified by counting hair cells in the cochlea. The study demonstrated that the Kanamycin ototoxicity regimen was safe, well tolerated, and detected early significant changes in hearing thresholds by DPOAE in a small group of mice. [3] |
| Alias | Ophtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfate |
| Molecular Weight | 582.58 |
| Formula | C18H38N4O15S |
| Cas No. | 25389-94-0 |
| Smiles | OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O |
| Relative Density. | 1.3619 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (85.82 mM) DMSO: Insoluble | ||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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